BDBM50142887 1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[3,4-d]pyrimidine::1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine::1-tert-butyl-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine::4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine::4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine::AG-1879::CHEMBL406845::PP2::US10544104, Compound 146::US10688093, Compound PP2 (Pfizer)::US11701353, PP2 (Pfizer)::US9765037, Compound 146::cid_4878

SMILES CC(C)(C)n1nc(-c2ccc(Cl)cc2)c2c(N)ncnc12

InChI Key InChIKey=PBBRWFOVCUAONR-UHFFFAOYSA-N

Data  8 KI  28 IC50  3 Kd  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50142887   

TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataKi:  0.794nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataKi:  60nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  4nMAssay Description:Inhibition of p56 Lck tyrosine kinase in Jurkat cells where p56lck autophosphorylation is inhibited.More data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  4nMAssay Description:Inhibition of p56lck autophosphorylationChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  4nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed